Women’s Health & Gynecology

Factor XII, (Hageman factor) is a serine protease zymogen that, when activated, initiates the intrinsic pathway of blood coagulation. Patients with Factor XII deficiency do not have excessive bleeding tendency despite prolongation of the activated partial thromboplastin time (APTT) in their serum. Postpartum Hemorrhage (PPH) is a potentially fatal obstetric complication, and its presence in the setting of a prolonged APTT can be worrisome to the treating obstetrician. Here, we report a case of PPH with prolonged APTT due to underlying factor XII deficiency who was successfully managed conservatively. The findings of this case report show that FXII deficient patients presenting with PPH can effectively be managed conservatively in the same way as other individuals with normal FXII levels.